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The expressions of SYT4, SYT9, and SYT14 were up-regulated, and negatively associated with their methylation levels in GC. Therefore, we comprehensively evaluated the expression, methylation, prognosis and immune significance of SYTs family members through bioinformatics analysis from the online databases in GC. However, only very few studies have investigated the expression profile and prognostic values of SYTs family members in gastric cancer (GC). Synaptotagmins (SYTs), constitute a family of 17 membrane-trafficking protein, palying crucial roles in the development and progression of human cancers. 6 Department of Pathology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.5 Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.4 Department of Gastroenterology, The First Affiliated Hospital of South China of University, South China of University, Hengyang, Hunan, China.3 Department of Gastroenterology, The Affiliated Zhuzhou Hospital of Xiangya Medical College, Zhuzhou, Hunan, China.2 Department of Hematology, The First Affiliated Hospital of South China of University, South China of University, Hengyang, Hunan, China.
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1 Department of Hematology, Yantian District People's Hospital, Shenzhen, Guangdong, China.